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Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity.

Archive ouverte | Cahuzac, Nathalie | CCSD

International audience. Fas ligand (FasL), a member of the TNF protein family, potently induces cell death by activating its matching receptor Fas. Fas-mediated killing plays a critical role in naturally and patholo...

Transgenic overexpression of a dominant negative mutant of FADD that, although counterselected during tumor progression, cooperates in L-myc-induced tumorigenesis.

Archive ouverte | Hueber, Anne-Odile | CCSD

International audience. Activation of the so-called death receptors, e.g., CD95/Fas/Apo-1, is a potent stimulus to trigger apoptosis. Overexpression of the C-terminal FADD deletion mutant FADD-DN blocks death recept...

Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.

Archive ouverte | Lückerath, Katharina | CCSD

International audience. Fas Ligand (FasL) not only induces apoptosis in Fas receptor-bearing target cells, it is also able to transmit signals into the FasL-expressing cell via its intracellular domain (ICD). Recent...

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