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p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.

Archive ouverte | Thévenot, Emmanuelle | CCSD

International audience. Mutations in the p21-activated kinase 3 gene (pak3) are responsible for nonsyndromic forms of mental retardation. Expression of mutated PAK3 proteins in hippocampal neurons induces abnormal d...

A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases.

Archive ouverte | Rousseau, Véronique | CCSD

p21-activated kinases (PAK) are involved in the control of cytoskeleton dynamics and cell cycle progression. Here we report the characterization of a new mammalian PAK3 mRNA that contains a 45-bp alternatively spliced exon. This e...

The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.

Archive ouverte | Kreis, Patricia | CCSD

The p21-activated kinases (PAK1), PAK2, and PAK3 are members of the PAK group I and share high sequence identity and common biochemical properties. PAK3 is specifically implicated in neuronal plasticity and also regulates cell cyc...

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