Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.

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Auray, L. | Alain, S. | Gourlain, K. | Imbert, Bm | Najioullah, F. | Champier, G. | Gouarin, S. | Carquin, J. | Houhou, N. | Garrigue, Isabelle | Ducancelle, A. | Thouvenot, D. | Mazeron, Mc | Fillet, Am

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We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.

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