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N-acyl homoserine lactones are degraded via an amidolytic activity in Comamonas sp. strain D1.

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Uroz, Stéphane | Dessaux, Yves | Oger, Philippe, M. | Chhabra, Siri Ram | Cámara, Miguel | Williams, Paul

Edité par CCSD ; Springer Verlag -

ABTSRACT: Comamonas strain D1 enzymatically inactivates quorum-sensing (QS) signal molecules of the N-acyl homoserine lactone (N-AHSL) family, and exhibits the broadest inactivation range of known bacteria. It degrades N-AHSL with acyl-side chains ranging from 4 to 16 carbons, with or without 3-oxo or 3-hydroxy substitutions. N-AHSL degradation yields HSL but not N-acyl homoserine: strain D1 therefore harbors an amidohydrolase activity. Strain D1 is the fifth bacterium species in which an N-AHSL amidohydrolase is described. Consistent with its N-AHSL degradation ability, strain D1 efficiently quenches various QS-dependent functions in other bacteria, such as violacein production by Chromobacterium violaceum and pathogenicity and antibiotic production in Pectobacterium.

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