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Inflammatory pain upregulates spinal inhibition via endogenous neurosteroid production

Archive ouverte | Poisbeau, Pierrick | CCSD

Inhibitory synaptic transmission in the dorsal horn (DH) of the spinal cord plays an important role in the modulation of nociceptive messages because pharmacological blockade of spinal GABAA receptors leads to thermal and mechanic...

Fast Nongenomic Effects of Steroids on Synaptic Transmission and Role of Endogenous Neurosteroids in Spinal Pain Pathways

Archive ouverte | Schlichter, Rémy | CCSD

Steroids exert long-term modulatory effects on numerous physiological functions by acting at intracellular/nuclear receptors influencing gene transcription. Steroids and neurosteroids can also rapidly modulate membrane excitabilit...

Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABAA miniature IPSCs in lamina II of the spinal cord

Archive ouverte | Keller, Anne Florence | CCSD

International audience. In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABA(A) and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell ...

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