Helium optically pumped magnetometers can detect epileptic abnormalities as well as squids as shown by intracerebral recordings

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Badier, Jean-Michel | Schwartz, Denis | Bénar, Christian-George | Kanzari, Khoubeib | Daligault, Sébastien | Romain, Rudy | Mitryukovskiy, Sergey | Fourcault, William | Josselin, Vincent | Le Prado, Matthieu | Jung, Julien | Palacios-Laloy, Augustin | Romain, Carron | Bartolomei, Fabrice | Labyt, Etienne | Bonini, Francesca

Edité par CCSD ; Society for Neuroscience -

International audience. Magnetoencephalography based on superconducting quantum interference devices (SQUIDs) has been shown to improve the diagnosis and surgical treatment decision for presurgical evaluation of drug-resistant epilepsy. Still, its use remains limited because of several constraints such as cost, fixed helmet size, and the obligation of immobility. A new generation of sensors, optically pumped magnetometers (OPMs), could overcome these limitations. In this study, we validate the ability of helium-based OPM ( 4 He-OPM) sensors to record epileptic brain activity thanks to simultaneous recordings with intracerebral EEG [stereotactic EEG (SEEG)]. We recorded simultaneous SQUIDs-SEEG and 4He-OPM-SEEG signals in one patient during two sessions. We show that epileptic activities on intracerebral EEG can be recorded by OPMs with a better signal-to noise ratio than classical SQUIDs. The OPM sensors open new venues for the widespread application of magnetoencephalography in the management of epilepsy and other neurologic diseases and fundamental neuroscience

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