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Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity

Archive ouverte | Maatouk, Layal | CCSD

International audience. The precise contribution of astrocytes in neuroinflammatory process occurring in Parkinson’s disease (PD) is not well characterized. In this study, using GRCx30CreERT2 mice that are condition...

Inflammation in Parkinson’s disease: role of glucocorticoids

Archive ouverte | Herrero, Maria-Trinidad | CCSD

International audience. Chronic inflammation is a major characteristic feature of Parkinson’s disease (PD). Studies in PD patients show evidence of augmented levels of potent pro-inflammatory molecules e.g., TNF-α, ...

Contribution of Glucocorticoids and Glucocorticoid Receptors to the Regulation of Neurodegenerative Processes

Archive ouverte | Vyas, Sheela | CCSD

International audience. Isolation of glucocorticoids (GCs) from adrenal glands followed by synthesis led rapidly to their first clinical application, about 70 years ago, for treatment of rheumatoid arthritis. To thi...

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