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Dealing with death as an outcome in supportive care clinical trials

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HALPERN, Scott D. | TEMEL, Jennifer S. | COURTRIGHT, Katherine R.

The past decade has witnessed a dramatic expansion in the number of randomized clinical trials (RCTs) testing palliative and other supportive care interventions, including methods to improve advance care planning, specialist and generalist palliative care delivery, and caregiver and clinician decision-making for patients with serious illnesses. However, like many welcome advances, this expansion in supportive care RCTs has engendered novel ethical and regulatory questions. Foremost among these questions is how to conceptualize and monitor mortality as an end point in trials of supportive care interventions.

http://dx.doi.org/10.1001/jamainternmed.2021.1816

Voir la revue «JAMA internal medicine»

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