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Examining adherence and dose effect of an early palliative care intervention for advanced heart failure patients
Article indépendant
CONTEXT: Research priority guidelines highlight the need for examining the "dose" components of palliative care (PC) interventions, such as intervention adherence and completion rates, that contribute to optimal outcomes.
OBJECTIVES: Examine the "dose" effect of PC intervention completion vs. non-completion on quality of life (QoL) and healthcare use in patients with advanced heart failure (HF) over 32 weeks.
METHODS: Secondary analysis of the ENABLE CHF-PC intervention trial for patients with New York Heart Association (NYHA) Class III/IV HF. 'Completers' defined as completing a single, in-person outpatient palliative care consultation (OPCC) plus six weekly, PC nurse coach-led telehealth sessions. 'Non-completers' were defined as either not attending the OPCC or completing < 6 telehealth sessions. Outcome variables were QoL and healthcare resource use (hospital days; emergency department visits). Mixed models were used to model dose effects for 'completers' vs 'non-completers' over 32 weeks.
RESULTS: Of 208 intervention group participants, 81 (38.9%) were classified as 'completers' with a mean age of 64.6 years; 72.8% were urban-dwelling; 92.5% had NYHA Class III HF. 'Completers' vs. 'non-completers' groups were well-balanced at baseline; however 'non-completers' did report higher anxiety (6.0 vs 7.0, p<0.05, d=0.28). Moderate, clinically-significant, improved QoL differences were found at 16-weeks in 'completers' vs. 'non-completers' (between-group difference: -9.71 (3.18), d=0.47, p=0.002) but not healthcare use.
CONCLUSION: Higher intervention completion rates of an early PC intervention was associated with QoL improvements in patients with advanced HF. Future work should focus on identifying the most efficacious "dose" of intervention components and increasing adherence to them.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02505425 KEY MESSAGE: Higher intervention completion of a HF early PC intervention (ENABLE CHF-PC) was associated with QoL improvements in patients with advanced HF. Future work should seek to enhance adherence to early PC interventions and identify other efficacious intervention "dose" components.
https://www.sciencedirect.com/science/article/pii/S0885392421001603?via%3Dihub
Voir la revue «JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 62»
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