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Archive ouverte | O'Brien, Darragh P. | CCSD

International audience. Once translocated into the cytosol of target cells, the catalytic domain (AC) of the adenylate cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by...

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Archive ouverte | Sotomayor-Pé, Ana-Cristina | CCSD

International audience. The past decade has seen a fundamental reappraisal of the protein structure-to-function paradigm because it became evident that a significant fraction of polypeptides are lacking ordered stru...

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Archive ouverte | Léger, Corentin | CCSD

International audience. Background Calmodulin (CaM) is an evolutionarily conserved eukaryotic multifunctional protein that functions as the major sensor of intracellular calcium signaling. Its calcium-modulated func...

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