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Actin subversion for productive Plasmodium hepatocyte invasion [Spotlight]

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Frischknecht, Freddy | Enninga, Jost

Edité par CCSD ; Elsevier -

International audience. Productive invasion of hepatocytes by Plasmodium sporozoites is a key step of infection. The parasites traverse hepatocytes before targeting one of them to form a parasitophorous vacuole for parasite expansion. Schepis et al. show the induction of membrane ruffling via host Rho GTPases by Plasmodium sporozoites facilitating productive invasion.

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