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Combinatorial Control of Th17 and Th1 Cell Functions by Genetic Variations in Genes Associated With the Interleukin-23 Signaling Pathway in Spondyloarthritis

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Coffre, Maryaline | Roumier, Mathilde | Rybczynska, Magda | Sechet, Emmanuel | Law, Helen | Gossec, Laure | Dougados, Maxime | Bianchi, Elisabetta | Rogge, Lars

Edité par CCSD ; Wiley -

International audience. Recent genome-wide association studies have revealed numerous genetic associations between specific single-nucleotide polymorphisms (SNPs) and immune-mediated inflammatory diseases. The current challenge is to identify associations of the genetic variants with effector mechanisms implicated in pathogenesis. This study was undertaken to investigate the link between genetic variation at loci associated with spondyloarthritis (SpA) and the effector function of CD4+ T lymphocyte subsets involved in chronic inflammatory disease.

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