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Clearance of pathogenic erythrocytes is maintained despite spleen dysfunction in children with sickle cell disease

Archive ouverte | Sissoko, Abdoulaye | CCSD

International audience. In children with sickle cell disease (SCD), splenectomy is immediately beneficial for acute sequestration crises and hypersplenism (ASSC/HyS) but portends a long‐term risk of asplenia‐related...

Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria

Archive ouverte | Henry, Benoît | CCSD

International audience. Background: In malaria-endemic areas, subjects from specific groups like Fulani have a peculiar protection against malaria, with high levels of IgM but also frequent anaemia and splenomegaly....

Adenine base editor–mediated correction of the common and severe IVS1-110 (G>A) β-thalassemia mutation

Archive ouverte | Hardouin, Giulia | CCSD

International audience. β-Thalassemia (BT) is one of the most common genetic diseases worldwide and is caused by mutations affecting β-globin production. The only curative treatment is allogenic hematopoietic stem/p...

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