Syracuse

A novel SARS-CoV-2 related coronavirus in bats from Cambodia

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Delaune, Deborah | Hul, Vibol | Karlsson, Erik, A. | Hassanin, Alexandre, A. | Ou, Tey Putita | Baidaliuk, Artem | Gámbaro, Fabiana | Prot, Matthieu | Tu, Vuong Tan | Chea, Sokha | Keatts, Lucy | Mazet, Jonna | Johnson, Christine, K. | Buchy, Philippe | Dussart, Philippe | Goldstein, Tracey | Simon-Loriere, Etienne | Duong, Veasna

Edité par CCSD ; Nature Publishing Group -

International audience. Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled in the Yunnan province, China. Here we describe the identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010. Metagenomic sequencing identifies nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely related to SARS-CoV-2, with the exception of a region of the spike, which is not compatible with human ACE2-mediated entry. The discovery of these viruses in a bat species not found in China indicates that SARS-CoV-2 related viruses have a much wider geographic distribution than previously reported, and suggests that Southeast Asia represents a key area to consider for future surveillance for coronaviruses.

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