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Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis

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Pasca, Maria Rosalia | Guglierame, Paola | Arcesi, Fabio | Bellinzoni, Marco | de Rossi, Edda | Riccardi, Giovanna

Edité par CCSD ; American Society for Microbiology -

International audience. The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis . The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m -chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.

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