Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”

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Kamphuis, Jasper, B J | Worrall, William, P M | Stackowicz, Julien | Mougel, Aurélie | Mauré, Emilie | Conde, Eva | Bruhns, Pierre | Guilleminault, Laurent | Gaudenzio, Nicolas | Chen, Jinmiao | Gentek, Rebecca | Reber, Laurent, L

Edité par CCSD ; American Association for the Advancement of Science (AAAS) -

International audience. Taniguchi et al . (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about the validity of some of the conclusions.

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