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Cytokines: IL-21 joins the γc-dependent network?

Archive ouverte | Vosshenrich, Christian A. J. | CCSD

International audience. The discovery of the cytokine IL-21 adds another member to the ever-growing list of small secreted molecules that have potent effects on lymphoid cells. Initial characterization of the IL-21 ...

Conditional genetic ablation mouse models as a tool to study cancer immunosurveillance in vivo

Archive ouverte | Dupont, Magali | CCSD

International audience. Over the last decades, it has been established that the immune system is crucial for the impediment of cancer development by recognizing and destroying transformed cells. This process has bee...

Developmental programming of natural killer and innate lymphoid cells

Archive ouverte | Vosshenrich, Christian A. J. | CCSD

International audience. In recent years we have witnessed a blooming interest in innate lymphoid cell (ILC) biology thanks to the discovery of novel lineages of ILC that are phenotypically and functionally distinct ...

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