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The functional specificity of CDC42 isoforms is caused by their distinct subcellular localization

Archive ouverte | Ravichandran, Yamini | CCSD

Posted May 03, 2023 on bioRxiv.. The small G-protein CDC42 is an evolutionary conserved polarity protein and a key regulator of numerous polarized cell functions, including directed cell migration. In vertebrates, a...

The distinct localization of CDC42 isoforms is responsible for their specific functions during migration

Archive ouverte | Ravichandran, Yamini | CCSD

International audience. The small G-protein CDC42 is an evolutionary conserved polarity protein and a key regulator of polarized cell functions, including directed cell migration. In vertebrates, alternative splicin...

Epithelial barrier dysfunction in desmoglein-1 deficiency

Archive ouverte | Polivka, Laura | CCSD

International audience. Mutations in the desmoplakin (DSP) and desmoglein-1 (DSG1) genes have been implicated in patients with the inherited inflammatory skin disease known as severe dermatitis, multiple allergies, ...

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