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Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme

Archive ouverte | Caval, Vincent | CCSD

International audience. The human APOBEC3A and APOBEC3B genes (A3A and A3B) encode DNA mutator enzymes that deaminate cytidine and 5-methylcytidine residues in single-stranded DNA (ssDNA). They are important sources...

Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus

Archive ouverte | Hallez, Camille | CCSD

International audience. Numerous human APOBEC3 cytidine deaminases have proven to be, inter alia, host cell restriction factors for retroviruses and hepadnaviruses. Although they can bind to genomic RNA and become e...

The rabbit as an orthologous small animal model for APOBEC3A oncogenesis

Archive ouverte | Laude, Hélène | CCSD

International audience. APOBEC3 are cytidine deaminases that convert cytidine to uridine residues. APOBEC3A and APOBEC3B enzymes able to target genomic DNA are involved in oncogenesis of a sizeable proportion of hum...

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