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Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients

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Jadid, Fatima Zahra | Chihab, Hajar | Alj, Hanane Salih | Elfihry, Raouia | Zaidane, Imane | Tazi, Sanaa | Badre, Wafaa | Marchio, Agnès | El Filali, Kamal Marhoum | Tahiri, Mohammed | Saile, Rachid | Pineau, Pascal | Ezzikouri, Sayeh | Benjelloun, Soumaya

Edité par CCSD ; Elsevier -

International audience. Chronic Hepatitis C is one of the most important risk factors of liver cirrhosis and hepatocellular carcinoma. Before reaching these ultimate steps, insulin resistance triggered by hepatitis C virus infection is known to participate in the progression of liver disease. The present study aims to investigate the influence of two functional polymorphisms on SOCS3 mRNA expression and on the outcomes of CHC progression in a North African context.

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