Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis

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Frémond, M.-L. | Pérot, P. | Muth, E. | Cros, G. | Dumarest, M. | Mahlaoui, N. | Seilhean, D. | Desguerre, I. | Hébert, C. | Corre-Catelin, N. | Neven, B. | Lecuit, M. | Blanche, S. | Picard, C. | Eloit, Marc

Edité par CCSD ; Oxford University Press -

International audience. A boy with X-linked agammaglobulinemia experienced progressive global motor decline, cerebellar syndrome, and epilepsy. All standard polymerase chain reactions for neurotropic viruses were negative on cerebrospinal fluid and brain biopsy. Next-generation sequencing allowed fast identification of a new astrovirus strain (HAstV-VA1/HMO-C-PA), which led to tailor the patient's treatment, with encouraging clinical monitoring over 1 year.

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