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Species-specific impact of the autophagy machinery on Chikungunya virus infection

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Judith, Delphine | Mostowy, Serge | Bouraï, Mehdi | Gangneux, Nicolas | Lelek, Mickaël | Lucas-Hourani, Marianne | Cayet, Nadège | Jacob, Yves | Prevost, Marie-Christine | Pierre, Philippe | Tangy, Fréderic | Zimmer, Christophe | Vidalain, Pierre-Olivier | Couderc, Thérèse | Lecuit, Marc

Edité par CCSD ; EMBO Press -

Comment in : Macroautophagy--friend or foe of viral replication? [EMBO Rep. 2013]. International audience. Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52-but not its mouse orthologue-interacts with the non-structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity.

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