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Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells

Archive ouverte | Huntington, Nicholas D. | CCSD

International audience. Protection of epithelial and mucosal surfaces is required for survival. The recent discovery of a diverse array of innate lymphoid cells that lie immediately beneath these surfaces has unexpe...

Developmental pathways that generate natural-killer-cell diversity in mice and humans

Archive ouverte | Vosshenrich, Christian A. J. | CCSD

International audience. Natural killer (NK) cells are large granular lymphocytes capable of producing inflammatory cytokines and spontaneously killing malignant, infected or 'stressed' cells. These NK-cell functions...

Cutting Edge: A Thymocyte-Thymic Epithelial Cell Cross-Talk Dynamically Regulates Intrathymic IL-7 Expression In Vivo

Archive ouverte | Alves, Nuno, L | CCSD

International audience. Thymic epithelial cells (TECs) are the predominant intrathymic source of the essential thymopoietin IL-7. Whether thymocyte-TEC interactions have a role in the regulation of IL-7 expression i...

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