Afficher la couverture 'Mitotic bookmarking in development and stem cells | Festuccia, Nicola' en grand format
/5

0 avis

Mitotic bookmarking in development and stem cells

Archive ouverte

Festuccia, Nicola | González, Inma | Owens, Nick | Navarro Gil, Pablo

Edité par CCSD ; Company of Biologists -

International audience. The changes imposed on the nucleus, chromatin and its regulators during mitosis lead to the dismantlement of most gene regulatory processes. However, an increasing number of transcriptional regulators are being identified as capable of binding their genomic targets during mitosis. These so-called 'mitotic bookmarking factors' encompass transcription factors and chromatin modifiers that are believed to convey gene regulatory information from mother to daughter cells. In this Primer, we review mitotic bookmarking processes in development and stem cells and discuss the interest and potential importance of this concept with regard to epigenetic regulation and cell fate transitions involving cellular proliferation.

Suggestions

Du même auteur

Transcription factor activity and nucleosome organisation in mitosis

Archive ouverte | Navarro Gil, Pablo | CCSD

International audience. Mitotic bookmarking transcription factors (BFs) maintain the capacity to bind to their targets during mitosis, despite major rearrangements of the chromatin. While they were thought to propag...

CTCF confers local nucleosome resiliency after DNA replication and during mitosis

Archive ouverte | Owens, Nick | CCSD

International audience. The access of Transcription Factors (TFs) to their cognate DNA binding motifs requires a precise control over nucleosome positioning. This is especially important following DNA replication an...

The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells

Archive ouverte | Heurtier, Victor | CCSD

International audience. Transcription factor networks, together with histone modifications and signalling pathways, underlie the establishment and maintenance of gene regulatory architectures associated with the mol...

Chargement des enrichissements...