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Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

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Rice, Gillian | Meyzer, Candice | Bouazza, Naïm | Hully, Marie | Boddaert, Nathalie | Semeraro, Michaela | Zeef, Leo, A.H | Rozenberg, Flore | Bondet, Vincent | Duffy, Darragh | Llibre, Alba | Baek, Jinmi | Sambe, Mame | Henry, Elodie | Jolaine, Valerie | Barnerias, Christine | Barth, Magalie | Belot, Alexandre | Cances, Claude | Debray, François-Guillaume | Doummar, Diane | Fremond, Marie-Louise | Kitabayashi, Naoki | Lepelley, Alice | Levrat, Virginie | Melki, Isabelle | Meyer, Pierre | Nougues, Marie-Christine | Renaldo, Florence | Rodéro, Mathieu | Rodriguez, Diana | Roubertie, Agathe | Seabra, Luis | Uggenti, Carolina | Abdoul, Hendy | Tréluyer, Jean-Marc | Desguerre, Isabelle | Blanche, Stéphane | Crow, Yanick

Edité par CCSD ; Massachusetts Medical Society -

International audience. To the Editor:The Aicardi–Goutières syndrome is a genetic encephalopathy that is associated with childhood illness and death. The syndrome is hypothesized to be due to misidentification of self-derived nucleic acids as nonself and the subsequent induction of a type I interferon–mediated response that simulates an antiviral reaction.1 Endogenous retroelements, mobile genetic elements that can be transcribed to RNA and then to DNA by reverse transcription, constitute 40% of the human genome and represent a potential source of immunostimulatory nucleic acid in patients with this syndrome.2

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