Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection

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Jeannin, Patricia | Chaze, Thibault | Gianetto, Quentin, Giai | Matondo, Mariette, I | Gout, Olivier | Gessain, Antoine, S | Afonso, Philippe

Edité par CCSD ; Nature Publishing Group -

International audience. Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a biomarker of systemic response to infection and/ or disease progression. In this study, we aimed at describing alterations in the protein content of plasma EVs upon infection with the human T-lymphotropic retrovirus type 1 (HTLV-1). HTLV-1 is the etiological agent of a lymphoproliferative disease (ATL) and a series of inflammatory diseases, including a neurodegenerative inflammatory disease (HAM/TSP). We found that plasma EVs are more abundant and smaller in HTLV-1 asymptomatic carriers or HAM/TSP patients when compared to uninfected healthy donors. Moreover, EVs from HTLV-1 infected donors contain markers of metabolic and mitochondrial stress.

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