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Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

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Moura, Ines | Monot, Marc | Tani, Chiara | Spigaglia, Patrizia | Barbanti, Fabrizio | Norais, Nathalie | Dupuy, Bruno | Bouza, Emilio | Mastrantonio, Paola

Edité par CCSD ; American Society for Microbiology -

International audience. Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.

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