International Spread of an Epidemic Population of Salmonella enterica Serotype Kentucky ST198 Resistant to Ciprofloxacin

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Le Hello, S. | Hendriksen, R. S. | Doublet, B. | Fisher, I. | Nielsen, E. M. | Whichard, J. M. | Bouchrif, B. | Fashae, K. | Granier, S. A. | Jourdan-da Silva, N. | Cloeckaert, A. | Threlfall, E. J. | Angulo, F. J. | Aarestrup, F. M. | Wain, J. | Weill, F.-X.

Edité par CCSD ; Oxford University Press -

International audience. National Salmonella surveillance systems from France, England and Wales, Denmark, and the United Statesidentified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displayinghigh-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002(3 cases) to 2008 (174 cases). These isolates belonged to a single clone defined by the multilocus sequence typeST198, the XbaI-pulsed-field gel electrophoresis cluster X1, and the presence of the Salmonella genomic island1 variant SGI1-K. This clone was probably selected in 3 steps in Egypt during the 1990s and the early 2000sand has now spread to several countries in Africa and, more recently, in the Middle East. Poultry has beenidentified as a potential major vehicle for infection by this clone. Continued surveillance and appropriate controlmeasures should be implemented by national and international authorities to limit the spread of this strain.

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