Afficher la couverture 'Two-component systems and toxinogenesis regulation in Clostridium botulinum | Connan, Chloé' en grand format
/5

0 avis

Two-component systems and toxinogenesis regulation in Clostridium botulinum

Archive ouverte

Connan, Chloé | Popoff, Michel R.

Edité par CCSD ; Elsevier -

International audience. Botulinum neurotoxins (BoNTs) are the most potent toxins ever known. BoNTs associate with non-toxic proteins to form complexes of various sizes. Toxin production is highly regulated through complex networks of regulatory systems involving an alternative sigma factor, BotR, and at least 6 two-component systems (TCSs). TCSs allow bacteria to sense environmental changes and to respond to various stimuli by regulating the expression of specific genes at a transcriptional level. This review aims to highlight the role of TCSs as a central point in the regulation of toxin production in C. botulinum.

Suggestions

Du même auteur

Preferential Entry of Botulinum Neurotoxin A Hc Domain through Intestinal Crypt Cells and Targeting to Cholinergic Neurons of the Mouse Intestine

Archive ouverte | Couesnon, Aurélie | CCSD

Botulism, characterized by flaccid paralysis, commonly results from botulinum neurotoxin (BoNT) absorption across the epithelial barrier from the digestive tract and then dissemination through the blood circulation to target auton...

Two-Component Systems Are Involved in the Regulation of Botulinum Neurotoxin Synthesis in Clostridium botulinum Type A Strain Hall

Archive ouverte | Connan, Chloé | CCSD

International audience. Clostridium botulinum synthesizes a potent neurotoxin (BoNT) which associates with non-toxic proteins (ANTPs) to form complexes of various sizes. The bont and antp genes are clustered in two ...

Regulation of toxin synthesis in Clostridium botulinum and Clostridium tetani

Archive ouverte | Connan, Chloé | CCSD

International audience. Botulinum and tetanus neurotoxins are structurally and functionally related proteins that are potent inhibitors of neuroexocytosis. Botulinum neurotoxin (BoNT) associates with non-toxic prote...

Chargement des enrichissements...