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Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.

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Bozzini, Tiziana | Botta, Giorgia | Delfino, Michela | Onofri, Silvano | Saladino, Raffaele | Amatore, Donatella | Sgarbanti, Rossella | Nencioni, Lucia | Palamara, Anna Teresa

Edité par CCSD ; Elsevier -

Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties.

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