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Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles.

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La Regina, Giuseppe | Gatti, Valerio | Famiglini, Valeria | Piscitelli, Francesco | Silvestri, Romano

Edité par CCSD ; ACS -

International audience. We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.

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