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Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection

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Jost, Stephanie | Moreno-Nieves, Uriel | Garcia-Beltran, Wilfredo | Rands, Keith | Reardon, Jeff | Toth, Ildiko | Piechocka-Trocha, Alicja | Altfeld, Marcus | Addo, Marylyn

Edité par CCSD ; BioMed Central -

International audience. Natural killer (NK) cells constitutively express high levels of Tim-3, an immunoregulatory molecule recently proposed to be a marker for mature and functional NK cells. Whether HIV-1 infection modulates the expression of Tim-3 on NK cells, or the levels of its ligand Galectin-9 (Gal-9), and how signaling through these molecules affects the NK cell response to HIV-1 remains inadequately understood.

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