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Death and the retrovirus.

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Vartanian, Jean Pierre | Sommer, Peter | Wain-Hobson, Simon

Edité par CCSD ; Elsevier -

International audience. A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.

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