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Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.

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Guetard, Denise | Greco, Raffaella | Cervantes Gonzalez, Minerva | Celli, Susanna | Kostrzak, Anna | Langlade-Demoyen, Pierre | Sala, Francesco | Wain-Hobson, Simon | Sala, Monica

Edité par CCSD ; Elsevier -

International audience. Transgenic tobacco plants expressing a HIV-1 polyepitope associated with hepatitis B (HBV) virus-like particles (VLPs) were previously described. It is demonstrated here that oral administration of these transgenic plants to humanized HSB mice to boost DNA-priming can elicit anti-HIV-1 specific CD8+ T cell activation detectable in mesenteric lymph nodes. Nevertheless, a significant regulatory T cell activation was induced in vivo by the vaccination protocols. The balance between tolerance and immunogenicity remains the main concern in the proof of concept of plant-based vaccine.

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