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2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.

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Bajramovic, Jeffrey J | Volmer, Romain | Syan, Sylvie | Pochet, Sylvie | Gonzalez-Dunia, Daniel

Edité par CCSD ; American Society for Microbiology -

International audience. Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.

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