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Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques

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Darricau, Morgane | Kulifaj, Valentine | Arotcarena, Marie-Laure | Li, Qin | Katsinelos, Taxiarchis | Mcewan, William | Xilouri, Maria | Dehay, Benjamin | Bezard, Erwan | Planche, Vincent

Edité par CCSD ; Nature -

International audience. The influence of Lewy body (LB) and tau co-pathologies is increasingly acknowledged as putatively affecting neurodegeneration and clinical phenotypes. Here, we injected rhesus macaques with LB fractions or/and tau seeds derived from patients brains into distinct brain areas connected to the mesencephalon. Compared to control macaques, we observed increased mesencephalic staining of pathological α-synuclein and tau, as well as nigrostriatal dopaminergic neuronal loss, with a cumulative effect of co-pathology.

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