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Archive ouverte | Bouroumeau, Antonin | CCSD

International audience. R-CHOP immuno-chemotherapy significantly improved clinical management of diffuse large B-cell lymphoma (DLBCL). However, 30\textendash 40% of DLBCL patients still present a refractory disease...

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Archive ouverte | Bouroumeau, Antonin | CCSD

International audience. Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous entity, in which the first-line treatment currently consists of an immuno-chemotherapy regimen (R-CHOP). However, around 30...

BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas

Archive ouverte | Delrieu, Loris | CCSD

International audience. Background MYC-driven lymphomas are a subset of B-cell lymphomas characterized by genetic alterations that dysregulate the expression of the MYC oncogene. When overexpressed, typically throug...

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