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C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

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Faugeroux, Vanessa | Génisson, Yves | Andrieu-Abadie, Nathalie | Colié, Sandra | Levade, Thierry | Baltas, Michel

Edité par CCSD ; Royal Society of Chemistry -

International audience.

The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.

Scheme 1 Structure of the ceramide, of the GCS inhibitor candidate 1 and of its synthetic precursor.

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