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Targeting TNF alpha as a novel strategy to enhance CD8 + T cell-dependent immune response in melanoma?

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Bertrand, Florie | Rochotte, Julia | Colacios, Céline | Montfort, Anne | Andrieu-Abadie, Nathalie | Levade, Thierry | Benoist, Hervé | Ségui, Bruno

Edité par CCSD ; Taylor & Francis -

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Tumor Necrosis Factor a (TNF) is a pleiotropic cytokine exhibiting a dual activity in oncoimmunology, either acting as a cytotoxic effector produced by leukocytes or behaving as an immunosuppressive molecule. We have just discovered that TNF signaling impairs the accumulation of tumor-infiltrating CD8 C T lymphocytes in experimental melanoma.

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