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Distinct Regulation of EZH2 and its Repressive H3K27me3 Mark in Polyomavirus-Positive and -Negative Merkel Cell Carcinoma

Archive ouverte | Durand, Marie-Alice | CCSD

International audience. Merkel cell carcinoma (MCC) is an aggressive skin cancer for which Merkel cell polyomavirus integration and expression of viral oncogenes small T and Large T have been identified as major onc...

The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma

Archive ouverte | Mazziotta, Chiara | CCSD

International audience. Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is t...

DNA Damage Stress Control Is a Truncated Large T Antigen and Euchromatic Histone Lysine Methyltransferase 2–Dependent Central Feature of Merkel Cell Carcinoma

Archive ouverte | Bachiri, Kamel | CCSD

International audience. Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high mortality rate. Merkel cell polyomavirus causes 80% of MCCs, encoding the viral oncogenes small T and truncated large T (t...

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