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CO12.1 - A case-control study to identify potential genetic biomarkers related to cardiac diseases occurrence in childhood cancer survivors. CO12.1 - A case-control study to identify potential genetic biomarkers related to cardiac diseases occurrence in childhood cancer survivors

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Aba, N. | Belhechmi, S. | Fresneau, B. | El-Fayech, C. | Rubino, C. | Allodji, R. | Morel, E. | de la Grange, P. | Jolly, A. | Koscielny, S. | Vu-Bezin, G. | de Vathaire, F. | Teuff, G. Le | Haddy, N.

Edité par CCSD ; Elsevier Masson -

International audience. Survival rates in paediatric oncology continue to improve with current 5-year survival after treatment reaching 80%. However, Cardiac Disease (CD) is the most common non-cancerous long-term adverse effect in this population, causing long-term morbidity and early mortality. Indeed, exposition to anthracyclines/or radiotherapy where the heart was exposed is significantly associated with CD. Nevertheless, these treatments alone cannot explain the individual variability in the prevalence and severity of CD. The current study aims to identify genetic expression biomarkers associated with CD occurrence after childhood cancer treatment, and to build a genomic signature linked to this cardiotoxicity.

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