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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Archive ouverte | Bel Lassen, Pierre | CCSD

International audience. Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose me...

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

Archive ouverte | Belda, Eugeni | CCSD

International audience. Objectives: Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s...

Microbiome and metabolome features of the cardiometabolic disease spectrum

Archive ouverte | Fromentin, Sebastien | CCSD

International audience. Previous microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes, such as common, pre-morbid and co-morbid cond...

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