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Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

Archive ouverte | del Rosario, Ricardo | CCSD

International audience. Host cell chromatin changes are thought to play an important role in the pathogenesis of infectious diseases. Here we describe a histone acetylome-wide association study (HAWAS) of an infecti...

Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation

Archive ouverte | Kumar, Dilip | CCSD

International audience. Resistin is a key cytokine associated with metabolic and inflammatory diseases. Especially in East Asian populations, the expression levels are strongly influenced by genetic polymorphisms. M...

Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms

Archive ouverte | del Rosario, Ricardo Cruz-Herrera | CCSD

International audience. Most disease associations detected by genome-wide association studies (GWAS) lie outside coding genes, but very few have been mapped to causal regulatory variants. Here, we present a method f...

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