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Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025)

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Softic, Laurent | Brillet, Rozenn | Berry, François | Ahnou, Nazim | Nevers, Quentin | Morin-Dewaele, Margot | Hamadat, Sabah | Bruscella, Patrice | Fourati, Slim | Pawlotsky, Jean-Michel | Ahmed-Belkacem, Abdelhakim

Edité par CCSD ; American Society for Microbiology -

International audience. Cyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective concentration (EC 50 ) of 0.46 ± 0.04 μM. Alisporivir inhibited a postentry step of the SARS-CoV-2 life cycle. These results justify rapidly conducting a proof-of-concept phase 2 trial with alisporivir in patients with SARS-CoV-2 infection.

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