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Intravenous immunoglobulin induces IL-4 in human basophils by signaling through 1 surface-bound IgE

Archive ouverte | Galeotti, Caroline, C | CCSD

International audience. BACKGROUND: Therapeutic normal IgG or intravenous immunoglobulin (IVIG) exerts anti-inflammatory effects through several mutually nonexclusive mechanisms. Recent data in mouse models of autoi...

Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms

Archive ouverte | Das, Mrinmoy | CCSD

International audience. Basophils play an important role in orienting Th2 immune response, and in the pathogenesis of allergic and inflammatory disorders. However, the mechanism by which basophils are kept in check ...

Regulatory T cells induce activation rather than suppression of human basophils

Archive ouverte | Sharma, Meenu | CCSD

International audience. Basophils are a rare granulocyte population that have been associated with allergic and inflammatory responses. It is essential to understand the regulatory mechanisms by which basophils are ...

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