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Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

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Roumans, Kay, H M | Lindeboom, Lucas | Veeraiah, Pandichelvam | Remie, Carlijn, M E | Phielix, Esther | Havekes, Bas | Bruls, Yvonne, M H | Brouwers, Martijn, C G J | Ståhlman, Marcus | Alssema, Marjan | Peters, Harry, P F | de Mutsert, Renée | Staels, Bart | Taskinen, Marja-Riitta | Borén, Jan | Schrauwen, Patrick | Schrauwen-Hinderling, Vera, B

Edité par CCSD ; Nature Publishing Group -

International audience. Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.

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