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Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations

Archive ouverte | Gougelet, Angélique | CCSD

International audience. Objective: Hepatocellular carcinoma (HCC) is the most prevalent primary tumour of the liver. About a third of these tumours presents activating mutations of the β-catenin gene. The molecular ...

Antitumor activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations miR-34a oncogenicity in β-catenin-mutated liver cancer

Archive ouverte | Gougelet, Angélique | CCSD

International audience. Objective: Hepatocellular carcinoma (HCC) is the most prevalent primary tumor of the liver. About a third of these tumors presents activating mutations of the β-catenin gene. The molecular pa...

The concomitant loss of APC and HNF 4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β‐catenin activation

Archive ouverte | Sartor, Chiara | CCSD

International audience. Background & aims: Loss of hepatocyte nuclear factor-4α (HNF4α), a critical factor driving liver development and differentiation, is frequently associated with hepatocellular carcinoma (HCC)....

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