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Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome

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Maarouf, Adil | Ferré, Jean-Christophe | Zaaraoui, W | Le Troter, Arnaud | Bannier, Elise | Berry, Isabelle | Guye, Maxime | Pierot, Laurent | Barillot, Christian | Pelletier, Jean | Tourbah, Ayman | Edan, Gilles | Audoin, Bertrand | Ranjeva, Jean-Philippe

Edité par CCSD ; SAGE Publications -

International audience. Macrophages are important components of inflammatory processes in multiple sclerosis, closely linked to axonal loss, and can now be observed in vivo using ultra-small superparamagnetic iron oxide (USPIO). In the present 1-year longitudinal study, we aimed to determine the prevalence and the impact on tissue injury of macrophage infiltration in patients after the first clinical event of multiple sclerosis.

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