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Response to comments on ‘Competing designs for drug combination in phase I dose-finding clinical trials’ by G. Yin, R. Lin and N. Wages

Archive ouverte | Riviere, Marie-Karelle | CCSD

International audience. As pointed out by Yin and Lin, and Wages, designs for drug-combination trials need to be rigorously evaluated. In our paper, we performed an extensive sensitivity analysis (with some of the r...

dfcomb: An R-package for phase I/II trials of drug combinations

Archive ouverte | Riviere, Marie-Karelle | CCSD

International audience. In this paper, we present the dfcomb R package for the implementation of a single prospective clinical trial or simulation studies of phase I combination trials in oncology. The aim is to pre...

On Multi-Armed Bandit Designs for Dose-Finding Trials

Archive ouverte | Aziz, Maryam | CCSD

International audience. We study the problem of finding the optimal dosage in early stage clinical trials through the multi-armed bandit lens. We advocate the use of the Thompson Sampling principle, a flexible algor...

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