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Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming. La reprogrammation épigénétique induite par la stimulation chronique du TCR dévoile une nouvelle cible thérapeutique associée à la signalisation des récepteurs NK dans les lymphomes T périphériques

Archive ouverte | Carras, Sylvain | CCSD

International audience. Peripheral T cell lymphomas (PTCLs) represent a significant unmet medical need with dismal clinical outcomes. The T cell receptor (TCR) is emerging as a key driver of T lymphocyte transformat...

CD1d-restricted peripheral T cell lymphoma in mice and humans

Archive ouverte | Bachy, Emmanuel | CCSD

International audience. Peripheral T cell lymphomas (PTCLs) are a heterogeneous entity of neoplasms with poor prognosis, lack of effective therapies, and a largely unknown pathophysiology. Identifying the mechanism ...

BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1

Archive ouverte | Delage, Lorric | CCSD

International audience. Abstract Understanding the functional role of mutated genes in cancer is required to translate the findings of cancer genomics into therapeutic improvement. BTG1 is recurrently mutated in the...

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